Dr. McGraw has been awarded a new grant, the NIH K08 Mentored Clinical Scientist Research Career Development Award to support his work over the next 5 years. For these studies, Dr. McGraw will combine genetic and pharmacological approaches in zebrafish to understand the developmental and constitutive effects of slc6a1(GAT1) hypofunction. He will also develop a high-throughput cell-based assay for GAT1 function to identify compounds that boost GAT1 function — a possible therapy for patients with slc6a1 deficiency, MAE, and possibly other GGE.